BackgroundApproximately 7% of the general population is affected by an orphan disease, which, in the United States, is defined as affecting fewer than 1 in 1500 people. Disease awareness is often low and time-to-diagnosis delayed. Different legislations worldwide have created incentives for pharmaceutical companies to develop drugs for orphan diseases. A journalistic article in Bloomberg Businessweek has claimed that pharmaceutical companies have tried marketing orphan drugs by placing a specific disease into the popular television series “House, M.D.” which features diagnostic (...) journeys and was produced between 2004 and 2012. This study aimed to describe the presentation of orphan diseases in the television series “House, M.D.”, to test in an exploratory fashion the hypothesis that treatable orphan conditions are overrepresented in “House, M.D.” and to discuss whether such marketing practices may or may not be ethical.MethodsA list of all medical cases depicted in the television series “House, M.D.” was obtained and classified as orphan or non-orphan according to the Orphanet database. The ratios of orphan diseases among all diseases, such with an orphan drug designation and such with an orphan drug approval by the FDA were then compared with conservative approximations of real world conditions (chi-squared tests for equality of proportions). STROBE criteria were respected.ResultsOut of a total of n = 181 different medical diagnoses, n = 42 (23.2%) were orphan diseases. The difference in percentages in between “House, M.D.” and reality was not statistically significant for orphan diseases overall (p = 0.96), yet was statistically significantly higher for both orphan diseases with one or more orphan drug designations (p = 0.0192) and such with one or more approved orphan drugs (p < 0.0001).ConclusionsOrphan diseases with a designated and/or approved orphan drug were overrepresented in the television series “House, M.D.” with statistical significance while orphan diseases overall were not. This may be explained by (so far) undocumented efforts of pharmaceutical companies to place their orphan drugs in the television series, as described in the article in Bloomberg Businessweek. Further research is needed into marketing practices in popular and emerging media formats. (shrink)

I begin with a note about moral goodness as a quality, disposition, or trait of a person or human being. This has at least two different senses, one wider and one narrower. Aristotle remarked that the Greek term we translate as justice sometimes meant simply virtue or goodness as applied to a person and sometimes meant only a certain virtue or kind of goodness. The same thing is true of our word “goodness.” Sometimes being a good person means having all (...) the virtues, or at least all the moral ones; then goodness equals the whole of virtue. But sometimes, being a good person has a narrower meaning, namely, being kind, generous, and so forth. Thus, my OED sometimes equates goodness with moral excellence as a whole and sometimes with a particular moral excellence, viz., kindness, beneficence, or benevolence; and the Bible, when it speaks of God as being good sometimes means that God has all the virtues and sometimes only that he is kind, mereiful, or benevolent. When Jesus says, “Why callest thou me good: None is good, save one, that is God,” he seems to be speaking of goodness in the inclusive sense, but when the writer of Exodus has God himself say that he is “merciful and gracious, long-suffering, and abundant in goodness and truth,” God is using “goodness” in the narrower sense in which it means benevolence, for he goes on to make it clear that he is also just and severe. Similarly, “good will” may mean either “morally good will” in general, as it does in Kant, or it may mean only “benevolent will,” as it usually does; in “men of good will” it is perhaps ambiguous. (shrink)

Normative theories of obligation, moral and nonmoral value, and meta-ethical issues and theories are considered.

This essay, one of the last that Frankena wrote, provides a scrupulously detailed exploration of the various possible meanings of one of Sidgwick's most famous footnotes in the Methods Long intrigued by what Sidgwick had in mind when he said that he would explain how it came about that for moderns it is not tautologous to claim that one's own good is one's only reasonable ultimate end, Frankena uses this note as a point of departure for a penetrating review of (...) Sidgwick's insights and ambiguities on the differences between ancient and modern ethics. (shrink)

This is the text of The Lindley Lecture for 1961, given by William K. Frankena, an American philosopher.

K Williams; The Labour We Delight In, Journal of Philosophy of Education, Volume 32, Issue 2, 28 June 2008, Pages 293–303, https://doi.org/10.1111/1467-9752.000.

The debate over the central issue confronted in Closing--the role of the university and the liberal arts in the United States--has become increasingly urgent and contentious. The goal of this collection of essays is to consider what we can learn about the dilemmas confronting American culture through a consideration of both The Closing of the American Mind and the debate it has aroused. The contributors differ among themselves as to the validity of both the diagnoses and the solutions Bloom offers, (...) yet they do not engage in "Bloom-bashing" or hero-worship. The goal of the book is to place the debate over Closing into the larger context than can be achieved in a book review format. To provide the historical perspective that has been missing in the controversy over Bloom, included in this volume is Christopher Lasch's "The Great Experiment: Where Did it Go Wrong?" Also included are essays by other leading critics: John K. Roth, Frank Caucci, William K. Buckley, Milton R. Stern, Susan Bourgeois, Margaret C. Jones, Daniel Zins, Kenneth Alan Hovey, Bonnie A. Hain, John Peacock, Patricia L. Lundberg, Peter Siedlecki, Mark W. Roche, William Thickstun, Lorraine Clark, and Gerald Graff. This volume of essays does much to illuminate the issue surrounding The Closing of the American Mind. (shrink)

Japan’s economy has stagnated since the bursting of the twin real estate and stock bubbles in 1990. Construction employment rose after the bubbles burst despite a real estate glut.Systemic corruption is delaying recovery. The key is thedango—Japan’s system of bid rigging, which is pervasive in public construction. The firms rotate who will win the “competitive” bid. The bureaucrats leak the highest price bid that will be accepted in return for favors from the industry and lucrative sinecures when they retire. The (...) ruling politicians get kickbacks and ensure the adoption of enormous public construction programs.The result is that Japanese public and private capital flows are corruptly routed to uses that are not simply inefficient, but outright harmful to society. Pervasive corruption is the primary obstacle to Japanese economic health and political reform. (shrink)

An expansion of 3 lectures presented by the author in 1978 at the University of Michigan.

Taking reduction in the traditional deductive sense, the programmatic claim that most of genetics can be reduced by molecular genetics is defended as feasible and significant. Arguments by Ruse and Hull that either the relationship is replacement or at best a weaker form of reduction are shown to rest on a mixture of historical and logical confusions about the nature of the theories involved.

First steps are taken toward a formulation of quantum mechanics which avoids the use of probability amplitudes and is expressed entirely in terms of observable probabilities. Quantum states are represented not by state vectors or density matrices but by “probability tables,” which contain only the probabilities of the outcomes of certain special measurements. The rule for computing transition probabilities, normally given by the squared modulus of the inner product of two state vectors, is re-expressed in terms of probability tables. The (...) new version of the rule is surprisingly simple, especially when one considers that the notion of complex phases, so crucial in the evaluation of inner products, is entirely absent from the representation of states used here. (shrink)

This paper argues for the importance of approaching medicine, as a theoretical science, through values. The normative concepts of benefit and harm are held to provide a framework for the analysis of medicine which reflects the obligations of the doctor-patient relationship, suffices to define the key concept of medical relevance, yields a general necessary condition for the basic concepts of medicine, explains the role of such nonnormative conceptions as discomfort, dysfunction, and incapacity, and avoids the mistakes of other normative approaches (...) which hold that unhealthy conditions are disvaluable or should be treated. Neutralist analyses are criticized, especially those approaching health through proper functioning. (shrink)

Adolf Grünbaum, [1], and Philip Quinn, [7], have proposed two problems as sharpened versions of theses suggested by Pierre Duhem. Can an hypothesis which in itself has no observational consequences ever be falsified by the evidence? When a theory has observational consequences only in conjunction with auxiliary hypotheses and some of these consequences fail, can the theory always be reasonably defended by constructing alternative auxiliary hypotheses?

It is well known that Sidgwick finished his examination of “the methods of ethics” in some difficulty. Just what that difficulty was and how he came to be in it, we shall see in due course. This paper is written in the conviction that what he was doing is worth looking at again in the context of contemporary discussion.

I critically examine an argument, due to howard wettstein, purporting to show that sentences containing definite descriptions are semantically ambiguous between referential and attributive readings. Wettstein argues that many sentences containing nonidentifying descriptions--descriptions that apply to more than one object--cannot be given a Russellian analysis, and that the descriptions in these sentences should be understood as directly referential terms. But because Wettstein does not justify treating referential uses of nonidentifying descriptions differently than attributive uses of nonidentifying descriptions, his argument fails.

New discoveries about materials and solar energy raise the possibility of a long-tenn shift of mining, refining, and manufacturing from Earth’s surface to locations outside Earth’s ecosphere, allowing Earth to begin to relax back toward its natural state. A little-discussed ambivalence toward the potential of space exploration exists among environmentalists. One camp sees it as a human adventure that may allow a bold initiative to improve Earth; another camp shies away from “heavy technology” and thus distrusts efforts as massive as (...) space exploration or utilization. Due to impending resource depletion on Earth, we may have only until the mid-twenty-first century to pursue the promising potential of space exploration to alleviate environmental problems of Earth. Subsequently, there may be too litde industlial base to support vigorous exploration and exploitation of resources in space. (shrink)

Kantian ethics is both very much alive and very much under attack in recent moral philosophy, and so I propose to review some of the discussion, though I must say in advance that my review will have to be incomplete and oversimplified in various ways.

Kantian ethics is both very much alive and very much under attack in recent moral philosophy, and so I propose to review some of the discussion, though I must say in advance that my review will have to be incomplete and oversimplified in various ways.